Faculty Development Teacher Training Course
Faculty Development Teacher Training Course
Ph.D. in Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Dissertation Title: Design, Synthesis and Biological Studies of some Novel Diazepines and Pyrimidines.
Master of Pharmacy, The Maharaja Sayajirao University of Baroda, Vadodara, India.
B. Pharmacy, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, India.
SRM University, Chennai, India (January 2016 to March 2017)
Osaka University, Japan (November 2012 to October 2015)
Apicore Pharmaceuticals Ltd, Vadodara, Gujarat, India (January 2012 to October 2012)
Apicore Pharmaceuticals Ltd, Vadodara, Gujarat, India (December 2011 to January 2012)
Department of Chemistry, National Central University, Taiwan (August 2011 to November 2011)
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan (August 2009 to July 2011)
Department of Science and Technology (DST), Government of India, New Delhi, for the project entitled “Schmidt Reaction Based Strategy for the Synthesis of Biologically Active Molecules” at IIT Madras, Chennai (July, 2008 to August 2009)
Department of Science and Technology (DST), for the project entitled “Unit of Nanoscience and Technology” at IIT Madras, Chennai (November 2007 to July 2008)
Schmidt Based Strategy for the Synthesis of Biologically Active Moleculess
Department of Science and Technology, Govt. of India
R. Ramajayam, ‘Medicinal chemistry of vicinal diaryl scaffold: A mini review’ European Journal of Medicinal Chemistry, 1, 162, 2019.
Rajani Giridhar, Riyaj S. Tamboli, R. Ramajayam, Dhaval G. Prajapati, M. R. Yadav‘Assessment of antiplatelet activity of 2-aminopyrimidines’ European Journal of Medicinal Chemistry, 428, 50, 2012.
R.Ramajayam , Kian-Pin Tan, Po-Huang Liang ‘Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery’ -Biochemical Society Transactions (Invited Review) – 1371, 39, 2011.
R.Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, ‘Synthesis and Evaluation of Pyrazolone Compounds as SARS Coronavirus 3C-like Protease Inhibitors’ -Bioorganic Medicinal Chemistry, 7849, 18, 2010.
R.Ramajayam, Kian-Pin Tan, Hun-Ge Liu, Po-Huang Liang, ‘Synthesis, docking studies and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease’ -Bioorganic Medicinal Chemistry Letters, 3569, 20, 2010.
R.Ramajayam, Nilesh B. Nehra, Nouri Neamati, Mange Ram Yadav, Rajani Giridhar, ‘Synthesis and Anti-HIV-1 Integrase Activitiy of Cyano Pyrimidinones’ -Archiv der Pharmazie, 710, 342, 2009.
Dhaval G Prajapati, R. Ramajayam , Mange Ram Yadav, Rajani Giridhar, ‘The Search for Potent, Small Molecule NNRTIs: A Review’ -Bioorganic Medicinal Chemistry, 5744, 17, 2009.
R.Ramajayam. Rajani Giridhar, M. R. Yadav, R. Balaraman, Hakim Djaballah, David Shum, Constantin Radu, ‘Synthesis, Antileukemic and Antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines’ -European Journal of Medicinal Chemistry, 2004, 43, 2008.
R.Ramajayam, Rajani Giridhar, M. R. Yadav, Hakim Djaballah, David Shum, Constantin Radu, ‘Synthesis and Antiproliferative Activity of some Diaryldiazepines and Diarylpyrimidines’ -Journal of Enzyme Inhibition and Medicinal Chemistry, 716, 22, 2007.
R.Ramajayam, R.Giridhar, M. R. Yadav, ‘Current Scenario of 1,4-diazepines as potent biomolecules-A mini review’ -Mini Reviews in Medicinal Chemistry, 793, 7, 2007.
R.Ramajayam, R.Giridhar, M. R. Yadav, ‘Synthesis of Novel Substituted Diaryl-1,4-diazepines’ -Khimiya Geterotsiklicheskikh Soedinenii (Chemistry of Heterocyclic Compounds), 1042, 2006.
R.Ramajayam, R. Giridhar, M. R. Yadav, Erick De Clercq, Christophe Pannecouque, Dhaval G Prajapati, ‘Identification of Novel Non-Nucleoside Reverse Transcriptase Inhibitors Using Fragment-Based Lead Generation’ -Medicinal Chemistry Research, 475, 14, 2005.
R. Ramajayam, Kian-Pin Tan, Po-Huang Liang ‘Recent development of 3CL and 3C protease inhibitors for anti-coronavirus and anti- picornavirus drug discovery’: Presented in Joint Sino-UK Protein Society Symposium – a meeting to celebrate the centenary of the Biochemical Society, May 2011.
R. Ramajayam, R. Giridhar, M. R.Yadav, Design, synthesis and evaluation of 2,3-diaryl-1,4-diazepines as potential antiproliferative agents. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug. 28-Sept. 1, 2005 (2005), MEDI-344.
R. Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘2,3-substituted diaryl-6,7-dihydro-5H-1,4-diazepine as potential medicinal agents’ 57th Indian Pharmaceutical Congress, Hyderabad, Dec. 02 to 04 2005, Abstract no. BP-54.
Shitesh R. Patel, M.M.Ganesh, R.Ramajayam, Rajani Giridhar and Mange Ram Yadav, ‘16ξ-dimethylamine-3-pyrrolidino-5-androstane dimethiodide as a potential neuromuscular blocking agents’ 55th Indian Pharmaceutical Congress, Chennai, Dec. 19 to 21 2003, Abstract no. BP-41.
Introductory chemistry experiments are for the freshman students who will introduce to various methods and procedures used in the present day organic chemistry laboratories. They will explore the reactivity of organic compounds including common methods of separation, purification, and instrumental analysis. It covers the general techniques of organic synthesis and the use of common spectroscopic instrumentation. Students synthesize a variety of compounds and analyze the products through physical properties and spectroscopy. The course duration is seven week in a semester.
Organic Chemistry 1 is the compulsory first semester course for second year CBCMP students. This course focused on current theories of structure and mechanism in organic chemistry. The course emphasizes reaction mechanisms. Organic chemistry 1 course covers structure and bonding in organic molecules, reactivity, Functional group, stereoisomers, the chemistry of hydrocarbons (alkanes, alkenes, alkynes), alkyl halides and basic spectroscopy. The aim of the course is to develop for students who seeking professional degrees in chemistry and biology. Lecture is 3 hours per week. Total 15 weeks in a semester.
Organic Chemistry 2 is an optional second semester course for second year students. This course covers Delocalized Pi electron systems, aromaticity and the reactions of arenes, aldehydes, ketones, carboxylic acids and their derivatives, amines and heterocycles and their spectroscopy. Lecture is 3 hours per week. Total 15 weeks in a semester.
Organic Chemistry 3 is the advanced level and an optional course for third year students. The aim of this course is to give students an understanding of more advanced areas of organic synthesis. Key areas covered include: Oxidation and Reduction; Rearrangement reactions; Retrosynthesis; Reactions involved in synthesis of some pharmaceutical importance drugs and Natural products. A plenary lecture from invited speakers will be arranged for third year students to gain advance knowledge in the interdisciplinary research. Lecture is 3 hours per week. Total 15 weeks in a semester.
Orgainc Chemistry, 6th edition, by Peter Vollhardt & Neil Schore.
Sialidases are enzymes which can catalyze the hydrolysis of glycosidic linkage of terminal sialic acid (N-acetylneuraminic acid) residues in oligosaccharides and other glycoconjugates. Human sialidases are four types and classified on the basis of their localization.
NEU1 - Intralysosomal sialidase, NEU2 - Cytosolic sialidase, NEU3 - Plasma membrane-associated sialidase and NEU4 - mitochondrial membrane-associated sialidase.
These isoforms differ in their substrate specificities, enzymatic properties, and physiological functions. Human sialidases plays a wide variety of biological processes namely cell metabolism, cell differentiation, cell growth, and apoptosis including immune functions.
Sialic acids have also been found to be involved in the proliferation of cancer cells, where they are usually over-expressed on the surface glycoproteins of some cancer cell lines. Gangliosides, present on the plasma membrane of cancer cells, play an important role in the regulation of these cells. Specific human sialidase (NEU3) on gangliosides induces inhibition of apoptosis and promotes cancer cell mobility (metastasis) in some colon and rectal cancer cells.
We are currently interested in developing selective non carbohydrate inhibitors of human sialidase (NEU3).